Global Nitric Oxide Supplements Market Analysis (2024 – 2030)

As per the latest research findings, the global market for Nitric Oxide Supplements attained a value of $952.9 million in 2023 and is anticipated to achieve a market size of $1530.15 million by 2030. Throughout the analysis period spanning from 2024 to 2030, the market is poised to register a compound annual growth rate (CAGR) of 7%.

Industry Overview

In the last twenty years, there has been a significant evolution in physiology and pharmacology research driven by nitric oxide (NO). This highly reactive molecule plays a pivotal role in various physiological processes such as platelet activity, vasodilation, blood flow regulation, and mitochondrial respiration. The synthesis of NO involves two main physiological mechanisms: NO synthase (NOS)-dependent pathways and NOS-independent pathways. The amino acid L-arginine serves as the primary precursor in NOS-dependent synthesis, where NOS enzymes oxidize it to produce NO.

L-arginine, a specific class of amino acid, is naturally present in the human body and is also found in trace amounts in various food sources including peanuts, almonds, walnuts, and pecans. The demand for arginine supplementation arises from its essential role in bodily functions and its limited availability in nature. L-arginine supplements are known to be beneficial for various health conditions such as migraines and inflammation. They facilitate blood vessel relaxation, particularly advantageous for individuals with cardiovascular issues. The market growth is fueled by the expanding applications of L-arginine supplements across different spheres of daily life.

The incorporation of L-arginine supplements is recommended to fulfill the body's requirement for conditionally essential amino acids. Individuals with protein deficiencies or malnutrition concerns are advised to incorporate L-arginine supplements into their diet. Additionally, growing children require adequate L-arginine intake to support their development.

Impact of COVID-19 on the Industry

The COVID-19 pandemic has disrupted the conversion of arginine into finished products for practical use, leading to a reduction in product inventory and industry revenue. Supply chain disruptions have hindered L-arginine manufacturing, resulting in decreased store inventories and an imbalance between product supply and market demand.

Market Drivers

Rising demand for L-arginine in the fitness industry will drive the market growth

Increasing demand for L-arginine in the fitness industry is expected to propel market growth. Bodybuilders and fitness enthusiasts frequently utilize arginine supplements, thereby significantly influencing market demand. Furthermore, the inclusion of arginine in various health foods, beverages, and sports nutrition products for athletes contributes to market expansion as shifting consumer preferences prioritize health and fitness.

The surge in the usage of L-arginine in cosmetics and personal care

The rising utilization of L-arginine in cosmetics and personal care products indicates its versatile applications and diverse uses. Its incorporation in personal care and cosmetics products, owing to its moisturizing properties and ability to enhance collagen synthesis while protecting the skin from free radical damage, drives market expansion. Consumers are increasingly inclined to use L-arginine-based products due to its expanding benefits in personal care.

Market Restraints

The potential side effects associated with L-arginine usage pose challenges to market growth.

Apart from indigestion, nausea, headaches, bloating, diarrhea, gout, and blood irregularities, L-arginine may lead to other adverse effects such as exacerbation of asthma symptoms, impaired insulin sensitivity, and low blood pressure. Higher doses of L-arginine could worsen heartburn, ulcers, or digestive issues caused by medication, and may aggravate symptoms in individuals with herpes.

Global Market Analysis of Nitric Oxide Supplements by Type

• L- Arginine
• L- citrulline

The global market for nitric oxide supplements is categorized by two main types: L-arginine and L-citrulline. Within this segmentation, the L-arginine segment is projected to exhibit the highest Compound Annual Growth Rate (CAGR) due to its significant demand in the health and fitness sector as a performance-enhancing supplement. Anticipated growth in the pharmaceutical industry further fuels the demand for L-arginine. It is synthesized in laboratories and utilized as medication, primarily for conditions associated with heart and blood vessels such as high blood pressure, coronary artery disease, peripheral vascular disease, angina, as well as for recovery post-surgery and pre-eclampsia, a pregnancy-related complication marked by high blood pressure and protein presence in urine.

Global Market Analysis of Nitric Oxide Supplements by Application

• Health and Fitness
• Cosmetics & Personal Care

The expanding market is propelled by increasing demand for L-arginine as a dietary supplement. L-arginine's benefits range from addressing inflammation to alleviating migraines. Particularly beneficial for individuals with cardiovascular issues, L-arginine relaxes blood arteries. Research suggests its potential in alleviating symptoms of peripheral artery disease, angina, and improving heart failure patients' health. Additionally, L-arginine's immune-boosting properties aid in managing HIV-related weight loss symptoms.

Global Market Analysis of Nitric Oxide Supplements by Geography & Region

• North America
• Europe
• Asia-Pacific
• Latin America
• The Middle East and Africa

The market for arginine supplements is dominated by North America, followed by Europe, owing to significant expansions in the pharmaceutical sector and escalating healthcare expenses, which are projected to boost demand for arginine supplements. Notably, healthcare spending contributed around 17% to GDP in the United States and approximately 11.5% in Western Europe in 2015. Forecasts indicate a CAGR of 4.2% and 4.1% for healthcare industries in the U.S. and Western Europe, respectively, from 2016 to 2020. North America and Europe are expected to witness high CAGRs in their supplement markets during the projection period, with pharmaceutical products primarily imported from China to Western Europe.

China and India emerge as leading producers of arginine supplements globally, with India's pharmaceutical production expected to witness double-digit growth over the forecast period. The Asia Pacific region, housing approximately 62% of the global population, experiences increased demand for medications and dietary supplements due to aging populations and a surge in kidney and chronic disease patients, thereby driving the market for arginine supplements.

In the Middle East and Africa, rising government expenditures in the healthcare sector, particularly in GCC nations, contribute to the growing demand for arginine supplements, projected to expand consistently at a CAGR over the forecast period.

Global Nitric Oxide Supplements Market Key Players

1. Jarrow Formulas Inc.
2. Prinova Group LLC.
3. Glanbia Nutritionals Inc.
4. NOW Foods
5. Twinlab Corporation
6. Infinite Labs
7. Olympian Labs Inc.
8. Ajinomoto Group
9. Scientific Sports Nutrition Ltd.

Recent Developments in the Global Nitric Oxide Supplement Market

• Merger & Acquisition: In 2020, Jarrow Formulas, a manufacturer with a 40-year legacy, was acquired by private equity firm New Mountain Capital.
• Merger & Acquisition: In 2019, Glanbia Nutritionals acquired Watson, a U.S.-based producer and provider of premium customized nutrient premix, baking ingredients, edible film, and material conditioning solutions catering to the nutrition, food and beverage, personal care, and supplement industries.